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- Title
The Role of Radiation Therapy in Locally Advanced Breast Cancer.
- Authors
But-Hadžić, Jasna; Bilban-Jakopin, Cvetka; Hadžić, Vedran
- Abstract
The purpose of the study was to evaluate and compare the impact of postoperative radiotherapy, whether it was based on the clinical stage at presentation of the disease or on the pathological downstaged disease after initial chemotherapy for non-inflammatory locally advanced breast cancer (LABC). We retrospectively analyzed locoregional recurrence (LRR), relapse free survival (RFS), overall survival (OS) and disease free survival (DFS) in 55 patients treated for non-inflammatory LABC with neoadjuvant chemotherapy and surgery with or without radiotherapy. The mean follow-up was 55 months. The 3-year OS was 74%, DFS 73% and RFS 87%. The OS and DFS benefit was seen in those receiving radiation, with a mean OS of 89 months versus 68 months (p = 0.029) and mean DFS of 72 months versus 54 months (p = 0.029). Total LRR was 11% (8% versus 17% in the non-radiotherapy group, p = 0.349) and mean RFS of 95 months versus 86 months (p = 0.164). If the treatment planning was to be based on the original extent of the disease, then all patients in our study should have received adjuvant radiotherapy. Significantly lower OS and DFS without the addition of radiotherapy suggests that indication for radiation treatment should be based on the clinical pre-chemotherapy stage rather than the pathological post-chemotherapy stage. Radiation should therefore always be considered regardless of the response to initial chemotherapy for non-inflammatory LABC.
- Subjects
RADIOTHERAPY; POSTOPERATIVE care; DRUG therapy; ELECTROTHERAPEUTICS; BREAST cancer
- Publication
Breast Journal, 2010, Vol 16, Issue 2, p183
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/j.1524-4741.2009.00885.x