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- Title
Sustained virological response to peginterferon plus ribavirin in chronic hepatitis C genotype 1 patients is associated with a persistent Th1 immune response.
- Authors
TRAPERO‐MARUGÁN, M.; GARCÍA‐BUEY, L.; MUÑOZ, C.; QUINTANA, N. E.; MORENO‐MONTEAGUDO, J. A.; BORQUE, M. J.; FERNÁNDEZ, M. J.; SALVANÉS, F. R.; MEDINA, J.; MORENO‐OTERO, R.
- Abstract
Background An impairment of cellular immune response may contribute to the persistency of hepatitis C virus infection. Aim To analyse the Th1/Th2 cytokine profile in peripheral blood CD4+ and CD8+ T cells from patients with chronic hepatitis C (CHC) during treatment with pegylated interferon- α2a plus ribavirin and to correlate the Th1/Th2 balance with virological response (SVR). Methods Prospective longitudinal study: 44 naïve genotype 1 CHC patients received PEG-IFN α2a plus ribavirin for 48 weeks: 26 (59.1%) achieved a SVR, 13 relapsed (29.5%) and 5 (11.4%) were non-responders. Sixteen healthy controls were analysed. The production of IL-4, IFN γ and TNF α by CD4+ and CD8+ T cells was measured using flow cytometry, both in resting and phorbol-ester-stimulated cells. Results First three months of treatment: the synthesis of TNF α by phorbol-ester-stimulated-CD4+ T cells was higher in patients with SVR ( P < 0.01). At the end of treatment, SVR was associated with higher intracellular expression of IFN γ by stimulated-CD4+ and CD8+ T cells ( P < 0.05). At the end of follow-up, a higher intracellular expression of IFN γ by CD4+ T cells was associated with a SVR. Conclusions A Th1-type immune response was associated with achievement of a SVR, as indicated by the persistent elevation of intracellular IFN γ and TNF α.
- Subjects
CELLULAR immunity; CHRONIC diseases; VIRAL hepatitis; HEPATITIS C; RIBAVIRIN; MICROBIAL virulence -- Immunological aspects; IMMUNE response; GENETIC research
- Publication
Alimentary Pharmacology & Therapeutics, 2006, Vol 24, Issue 1, p117
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2006.02954.x