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- Title
Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer.
- Authors
Chiou, J.-F.; Liang, J.-A.; Hsu, W.-H.; Wang, J.-J.; Ho, S.-T.; Kao, A.
- Abstract
Our aim was to compare Taxol-hased chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). lmmunohistochemical analyses were performed on multiple nonconsecutive sections of' the biopsy specimens to detect Pgp and LPR expressions in 40 patients with advanced NSCLC before Taxol- based chemotherapy. The chemotherapy response was evaluated by clinical and radiological methods in the third month alter completion of treatment. No significant differences of prognostic factors (age, sex, body weight loss, performance status, tumor size, tumor stage, and tumor cell type) weight found between the 20 patients with good and the ,20 patients with poor responses The incidence difference of positive Pgp expressions between good anti poor responses was significant, however, the difference of LRP expression was not. We concluded that Taxol-based chemotherapy response of patients with NSCLC was related to Pgp but not LPR expression.
- Subjects
DRUG therapy; LUNG cancer diagnosis; DIAGNOSTIC specimens; CLINICAL indications
- Publication
Lung, 2003, Vol 181, Issue 5, p267
- ISSN
0341-2040
- Publication type
Article
- DOI
10.1007/s00408-003-1029-7