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- Title
Predictors of progression in autosomal dominant and autosomal recessive polycystic kidney disease.
- Authors
Benz, Eric G.; Hartung, Erum A.
- Abstract
Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are characterized by bilateral cystic kidney disease leading to progressive kidney function decline. These diseases also have distinct liver manifestations. The range of clinical presentation and severity of both ADPKD and ARPKD is much wider than was once recognized. Pediatric and adult nephrologists are likely to care for individuals with both diseases in their lifetimes. This article will review genetic, clinical, and imaging predictors of kidney and liver disease progression in ADPKD and ARPKD and will briefly summarize pharmacologic therapies to prevent progression.
- Subjects
POLYCYSTIC kidney disease; DISEASE progression; BIOMARKERS; GENETICS; DIAGNOSTIC imaging; AUTOSOMAL recessive polycystic kidney
- Publication
Pediatric Nephrology, 2021, Vol 36, Issue 9, p2639
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-020-04869-w