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- Title
Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology.
- Authors
Dogra, Samriti; Kaskel, Frederick
- Abstract
Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.
- Subjects
STEROID drugs; BIOMARKERS; DRUG resistance; KIDNEY glomerulus; GENETIC mutation; NEPHROTIC syndrome; PHARMACOGENOMICS; GENETIC testing; INDIVIDUALIZED medicine; CHILDREN; GENETICS
- Publication
Pediatric Nephrology, 2017, Vol 32, Issue 6, p965
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-016-3459-5