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- Title
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
- Authors
Trinei, Mirella; Giorgio, Marco; Cicalese, Angelo; Barozzi, Sara; Ventura, Andrea; Migliaccio, Enrica; Milia, Elisabetta; Padura, Ines Martin; Raker, Veronica A.; Maccarana, Marco; Petronilli, Valeria; Minucci, Saverio; Bernardi, Paolo; Lanfrancone, Luisa
- Abstract
Presents a study that investigated the molecular mechanisms underlying oxidative stress resistance of the p66Shc. Significance of reactive oxygen species to the theory of aging; Background on p66Shc; Analysis of the role of the p53 tumor suppressor in the regulation of oxidative stress-induced apoptosis.
- Subjects
REACTIVE oxygen species; P53 antioncogene; APOPTOSIS
- Publication
Oncogene, 2002, Vol 21, Issue 24, p3872
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205513