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- Title
Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases.
- Authors
Liang, Geoffrey; Zhu, Feng; Mirza, Ali I; Bar-Or, Amit; Bernstein, Charles N; Bonner, Christine; Forbes, Jessica D; Graham, Morag; Hart, Janace; Knox, Natalie C; Marrie, Ruth Ann; O'Mahony, Julia; Van Domselaar, Gary; Yeh, E Ann; Zhao, Yinshan; Banwell, Brenda; Waubant, Emmanuelle; Tremlett, Helen
- Abstract
Objective: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). Methods: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed. Results: Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus – Solobacterium did (p = 0.001). Conclusions: The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach.
- Subjects
DEMYELINATION; GUT microbiome; MULTIPLE sclerosis; DNA sequencing; MYELIN sheath diseases
- Publication
Multiple Sclerosis Journal, 2022, Vol 28, Issue 11, p1819
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585221079533