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- Title
Octylisothiazolinone, an additional cause of allergic contact dermatitis caused by leather: case series and potential implications for the study of cross-reactivity with methylisothiazolinone.
- Authors
Aerts, Olivier; Meert, Hans; Romaen, Elien; Leysen, Julie; Matthieu, Lucretia; Apers, Sandra; Lambert, Julien; Goossens, An
- Abstract
Background Octylisothiazolinone ( OIT) is used as an antifungal agent by the leather industry. Objectives To show sensitization to OIT from leather, and to highlight the potential implications when cross-reactivity between OIT and methylisothiazolinone ( MI) is studied. Methods Two patients with allergic contact dermatitis caused by a leather belt and shoes, respectively, were patch tested with methylchloroisothiazolinone ( MCI)/ MI, MI, MCI, OIT, and benzisothiazolinone ( BIT). High-performance liquid chromatography with ultraviolet detection ( HPLC-UV) was used to detect isothiazolinone derivatives in leather goods. Additionally, files of OIT-sensitized patients, observed at the KU Leuven department during the period 1990-2015, were retrospectively analysed. Results Both patients had been primarily sensitized to OIT, but the diagnosis in one of them could be achieved only when a higher patch test concentration of OIT (1000 ppm pet.) was used. HPLC-UV confirmed the presence of OIT in their leather goods. Non-relevant sensitization to MI was noted in both cases. Four additional cases of OIT sensitization from leather could be retrieved from the KU Leuven database. Conclusions Non-occupational sensitization to OIT from leather may occur. Patch test concentrations of >250 ppm pet. may be necessary for diagnosis, and to show cross-reactivity with MI. Safer use limits for OIT in the leather industry may be needed.
- Subjects
CONTACT dermatitis; LEATHER; CROSS reactions (Immunology); THIAZOLINES; HIGH performance liquid chromatography
- Publication
Contact Dermatitis (01051873), 2016, Vol 75, Issue 5, p276
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.12670