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- Title
The efficacy of inhibiting tumour necrosis factor α and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons.
- Authors
Nixon, R.; Bansback, N.; Brennan, A.
- Abstract
Objective. New treatments that inhibit the cytokines tumour necrosis factor α (TNFα) and interleukin 1 (IL-1) in the treatment of rheumatoid arthritis have proven clinical effect against placebo and methotrexate (MTX) in several clinical trials in early and late-stage disease and different severity groups. Since there are no head-to-head randomized controlled trials directly comparing the currently available treatments, etanercept, adalimumab, infliximab or anakinra, we perform a meta-analysis that adjusts for differences between study characteristics, and allows indirect comparisons between treatments.
- Subjects
CYTOKINES; TUMOR necrosis factors; INTERLEUKIN-1; RHEUMATOID arthritis treatment; METHOTREXATE; PLACEBOS; THERAPEUTICS
- Publication
Rheumatology, 2007, Vol 46, Issue 7, p1140
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kem072