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- Title
Enzymology of Ca 2+ -Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases.
- Authors
Guse, Andreas H.
- Abstract
Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine dinucleotide phosphate (NAADP). The enzymes involved are either NAD glycohydrolases CD38 or sterile alpha toll/interleukin receptor motif containing-1 (SARM1), or (dual) NADPH oxidases (NOX/DUOX). Enzymatic function(s) are reviewed and physiological role(s) in selected cell systems are discussed.
- Subjects
OXIDASES; NIACIN; ENZYMOLOGY; INTERLEUKIN receptors; ADENINE; NICOTINAMIDE adenine dinucleotide phosphate; NAD (Coenzyme); TOLL-like receptors
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 4, p675
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12040675