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- Title
Bioactive Polylactide Fibrous Materials Prepared by Crazing Mechanism.
- Authors
Khavpachev, Mukhamed A.; Trofimchuk, Elena S.; Nikonorova, Nina I.; Garina, Elisaveta S.; Moskvina, Marina A.; Efimov, Alexander V.; Demina, Varvara A.; Bakirov, Artem V.; Sedush, Nikita G.; Potseleev, Vladislav V.; Cherdyntseva, Tatiana A.; Chvalun, Sergei N.
- Abstract
Bioactive suture materials made of biodegradable polymers containing biologically active substances are increasingly demanded in contemporary surgical practice. Herein, the functional fibrous materials are produced by structural modification of polylactide (PLA) fibers according to the crazing mechanism in water–ethanol solutions. The threshold of ethanol concentration, at which the breaking elongation of the polymer substantially increases (up to 600–700%), is found to be 30 wt%. The crazing mechanism is employed to fill the porous structure of PLA fibers by different antiseptic substances (brilliant green, iodine, and fuchsin). PLA loaded by 0.8 wt% of brilliant green exhibits antimicrobial activity on Escherichia coli and Candida guilliermondii. The additive is released stepwise for a prolongated time period (2.5 months). The addition of 1–6 wt% iodine dramatically accelerates the polymer degradation in sodium‐phosphate buffer solution at 37 °C. The obtained filled fibers may possess great interest for producing suture materials with prolonged action of functional components and variable degradation times.
- Subjects
BUFFER solutions; POLYMER degradation; MATERIALS; ESCHERICHIA coli; FIBERS; BIODEGRADABLE materials; POLYLACTIC acid
- Publication
Macromolecular Materials & Engineering, 2020, Vol 305, Issue 7, p1
- ISSN
1438-7492
- Publication type
Article
- DOI
10.1002/mame.202000163