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- Title
Can HTLV-1 Infection Be a Potential Risk Factor for Atherosclerosis?
- Authors
Layegh, Parvaneh; Shoeibi, ali; Nikkhah, Karim; Ghabeli Juibary, ali; Raftari, Samaheh; Darbarpanah, Sahar; Boroumand, Reza; azarpazhooh, Mahmoudreza
- Abstract
Introduction: Chronic inflammations including infectious disorders such as HIV infection are now considered as risk factors for atherosclerosis. In this study, conducted for the first time on human subjects, human T-lymphotropic virus type 1 (HTLV-1) infection was examined as a potential risk factor for atherosclerosis. Materials and Methods: This is a matched-pair cross-sectional study on 58 HTLV-1-infected cases and 55 healthy control subjects. The subjects did not have any major cerebrovascular risk factors. Carotid intima-media thickness (IMT) was measured for each patient using the standard protocol of the Atherosclerosis Risk in Communities (ARIC) Study. Results: The mean age of the subjects was 42.9 ± 10.52 years, and males made up 33% of the population. The difference between the mean IMT of the infected case group and that of the healthy control group was significant (p < 0.05). Discussion: This study indicated that the HTLV-infected individuals showed a greater carotid IMT than the age- and sex-matched control subjects.Observing no other known risk factor for atherosclerosis, we concluded that this significant difference in IMT might support the hypothesis that HTLV-1 infection is an independent risk factor for atherogenesis. © 2014 S. Karger AG, Basel
- Subjects
HTLV diseases; ATHEROSCLEROSIS risk factors; INFLAMMATION; HIV infections; CEREBROVASCULAR disease risk factors; CAROTID intima-media thickness; CROSS-sectional method
- Publication
Intervirology, 2014, Vol 57, Issue 6, p365
- ISSN
0300-5526
- Publication type
Article
- DOI
10.1159/000365785