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- Title
Effects of the Complex of Panicum miliaceum Extract and Triticum aestivum Extract on Hair Condition.
- Authors
Choi, Nahyun; Kim, Ki Cheon; Jeong, Pan-Young; Kim, Bumsik
- Abstract
Proso millet (Panicum miliaceum L.) and common wheat (Triticum aestivum L.) have been used as major crops in multiple regions since ancient times, and they contain various nutrients that can affect human hair health. This study investigated the various biological effects of a complex of millet extract and wheat extract (MWC) on hair health. Human immortalized dermal papilla cells (iDPCs) for an in vitro study and an anagen-synchronized mouse model for an in vivo study were employed. These findings revealed that the application of the MWC in vitro led to an increase in the mRNA levels of antioxidant enzymes (catalase and SOD1), growth factors (IGF-1, VEGF, and FGF7), and factors related to hair growth (wnt10b, β-catenin) while decreasing inflammatory cytokine mRNA levels (IL-6 and TNFα). The mRNA levels of hair follicles (HFs) in the dorsal skin of the mouse model in the early and late telogen phases were also measured. The mRNA levels in the in vivo study showed a similar alteration tendency as in the in vitro study in the early and late telogen phases. In this model, MWC treatment elongated the anagen phase of the hair cycle. These findings indicate that the MWC can suppress oxidative stress and inflammation and may elongate the anagen phase by enhancing the growth factors involved in the wnt10b/β-catenin signaling pathway. This study suggests that the MWC might have significant potential as a functional food for maintaining hair health.
- Subjects
ANTIOXIDANT analysis; BIOLOGICAL models; FUNCTIONAL foods; IN vitro studies; INTERLEUKINS; IN vivo studies; ANIMAL experimentation; INFLAMMATION; ANTI-inflammatory agents; GROWTH factors; SUPEROXIDE dismutase; ANTIOXIDANTS; CATALASE; CELLULAR signal transduction; OXIDATIVE stress; GENE expression; HAIR follicles; RESEARCH funding; MESSENGER RNA; TUMOR necrosis factors; GRAIN; PLANT extracts; CELL lines; VASCULAR endothelial growth factors; WHEAT; MICE; PHARMACODYNAMICS
- Publication
Nutrients, 2023, Vol 15, Issue 20, p4411
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15204411