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- Title
Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Authors
Azuma, Naoki; Mawatari, Takashi; Saito, Yasuo; Tsukamoto, Masashi; Sampei, Masatoshi; Iwama, Yoshitaka
- Abstract
Bifidobacterium animalis subsp. lactis GCL2505 has been shown to have some positive effects on health, including improved defecation frequency and reduced visceral fat. These effects are thought to be due to GCL2505′s unique ability to reach the intestine in a viable form and proliferate after a single intake. This leads to an increased number of intestinal bifidobacteria. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to confirm that intake of GCL2505 and inulin (a prebiotic) improve cognitive function (n = 80). Participants consumed test drinks containing 1 × 1010 colony-forming units of GCL2505 per 100 g and 2.0 g of inulin per 100 g for 12 weeks. The change in cognitive function assessment scores was set as the primary endpoint. There were significant improvements in scores in the neurocognitive index domain, which is an assessment of overall cognitive function, in addition to overall attention, cognitive flexibility, and executive function domains. The intervention significantly increased the number of fecal bifidobacteria and affected the levels of several inflammatory markers. These results suggest that intake of GCL2505 and inulin improves cognitive function by improving the intestinal environment and alleviating inflammation.
- Subjects
THERAPEUTIC use of probiotics; COGNITION disorders; DIETARY fiber; BIFIDOBACTERIUM; COGNITIVE flexibility; EXECUTIVE function; BIOMARKERS; FOOD consumption; TREATMENT effectiveness; RANDOMIZED controlled trials; PLACEBOS; COMPARATIVE studies; BLIND experiment; DESCRIPTIVE statistics; ATTENTION; STATISTICAL sampling; INULIN
- Publication
Nutrients, 2023, Vol 15, Issue 19, p4175
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15194175