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- Title
Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial.
- Authors
Schmidt, Kelsey A.; Mokhtari, Pari; Holzhausen, Elizabeth A.; Alderete, Tanya L.; Allayee, Hooman; Nayak, Krishna S.; Sinatra, Frank R.; Pickering, Trevor A.; Mack, Wendy; Kohli, Rohit; Goran, Michael I.
- Abstract
Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested the efficacy of pediatric sugar reduction interventions. Therefore, in a parallel-design trial, we randomized Latino youth with obesity (BMI ≥ 95th percentile) [n = 105; 14.8 years] to control (standard diet advice) or sugar reduction (clinical intervention with a goal of ≤10% of calories from free sugar) for 12-weeks. Outcomes included changes in glucose tolerance and its determinants as assessed by a 2-h frequently sample oral glucose tolerance test, fasting serum lipid profile (total cholesterol, HDL, LDL, triglycerides, cholesterol:HDL), and inflammatory markers (CRP, IL-6, TNF- α ). Free sugar intake decreased in the intervention group compared to the control group [11.5% to 7.3% vs. 13.9% to 10.7% (% Energy), respectively, p = 0.02], but there were no effects on any outcome of interest (pall > 0.07). However, an exploratory analysis revealed that sugar reduction, independent of randomization, was associated with an improved Oral-disposition index (p < 0.001), triglycerides (p = 0.049), and TNF- α (p = 0.02). Dietary sugar reduction may have the potential to reduce chronic disease risks through improvements in beta-cell function, serum triglycerides, and inflammatory markers in Latino adolescents with obesity.
- Subjects
CARDIOVASCULAR disease prevention; CARDIOVASCULAR diseases risk factors; BIOMARKERS; RESEARCH; C-reactive protein; INTERLEUKINS; TRIGLYCERIDES; CHILDHOOD obesity; HISPANIC Americans; DIETARY sucrose; TREATMENT effectiveness; COMPARATIVE studies; DESCRIPTIVE statistics; TUMOR necrosis factors; RESEARCH funding; BODY mass index; GLUCOSE tolerance tests; DATA analysis software; SECONDARY analysis; LIPIDS; ADOLESCENCE
- Publication
Nutrients, 2023, Vol 15, Issue 15, p3338
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15153338