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- Title
L-Glutamine Supplementation Enhances Strength and Power of Knee Muscles and Improves Glycemia Control and Plasma Redox Balance in Exercising Elderly Women.
- Authors
Amirato, Gislene R.; Borges, Juliana O.; Marques, Daniella L.; Santos, Juliana M. B.; Santos, Carlos A. F.; Andrade, Marilia S.; Furtado, Guilherme E.; Rossi, Marcelo; Luis, Lais N.; Zambonatto, Raquel F.; Silva, Eliane B. da; Poma, Sarah O.; Almeida, Mariana M. de; Pelaquim, Renato L.; Santos-Oliveira, Laiane C. dos; Diniz, Vinicius L. Sousa; Passos, Maria E. P.; Levada-Pires, Adriana C.; Gorjão, Renata; Barros, Marcelo P.
- Abstract
We investigated the effects of oral L-glutamine (Gln) supplementation, associated or not with physical exercises, in control of glycemia, oxidative stress, and strength/power of knee muscles in elderly women. Physically active (n = 21) and sedentary (n = 23) elderly women aged 60 to 80 years were enrolled in the study. Plasma levels of D-fructosamine, insulin, reduced (GSH) and oxidized (GSSG) glutathione, iron, uric acid, and thiobarbituric acid-reactive substances (TBARs) (lipoperoxidation product), as well as knee extensor/flexor muscle torque peak and average power (isokinetic test), were assessed pre- and post-supplementation with Gln or placebo (30 days). Higher plasma D-fructosamine, insulin, and iron levels, and lower strength/power of knee muscles were found pre-supplementation in the NPE group than in the PE group. Post-supplementation, Gln subgroups showed higher levels of GSH, GSSG, and torque peak, besides lower D-fructosamine than pre-supplementation values. Higher muscle average power and plasma uric acid levels were reported in the PE + Gln group, whereas lower insulin levels were found in the NPE + Gln than pre-supplementation values. TBARs levels were diminished post-supplementation in all groups. Gln supplementation, mainly when associated with physical exercises, improves strength and power of knee muscles and glycemia control, besides boosting plasma antioxidant capacity of elderly women.
- Subjects
BLOOD sugar; SARCOPENIA; OXIDATIVE stress; MUSCLE strength; GLUTAMINE; WOMEN'S health; OLD age
- Publication
Nutrients, 2021, Vol 13, Issue 3, p1025
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13031025