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- Title
Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study.
- Authors
Goupille, Caroline; Frank, Philippe G.; Arbion, Flavie; Jourdan, Marie-Lise; Guimaraes, Cyrille; Pinault, Michelle; Body, Gilles; Chevalier, Stephan; Bougnoux, Philippe; Ouldamer, Lobna
- Abstract
In the present study, we investigated various biochemical, clinical, and histological factors associated with bone metastases in a large cohort of pre- and postmenopausal women with breast cancer. Two hundred and sixty-one consecutive women with breast cancer were included in this study. Breast adipose tissue specimens were collected during surgery. After having established the fatty acid profile of breast adipose tissue by gas chromatography, we determined whether there were differences associated with the occurrence of bone metastases in these patients. Regarding the clinical and histological criteria, a majority of the patients with bone metastases (around 70%) had tumors with a luminal phenotype and 59% of them showed axillary lymph node involvement. Moreover, we found a negative association between the levels of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in breast adipose tissue and the development of bone metastases in premenopausal women. No significant association was observed in postmenopausal women. In addition to a luminal phenotype and axillary lymph node involvement, low levels of n-3 LC-PUFA in breast adipose tissue may constitute a risk factor that contributes to breast cancer bone metastases formation in premenopausal women.
- Subjects
ADIPOSE tissues; BONE metastasis; BREAST tumors; GAS chromatography; LYMPH nodes; OMEGA-6 fatty acids; UNSATURATED fatty acids; WOMEN'S health; PHENOTYPES; PERIMENOPAUSE; RETROSPECTIVE studies; DESCRIPTIVE statistics
- Publication
Nutrients, 2020, Vol 12, Issue 12, p3832
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12123832