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- Title
In vitro cytotoxicity of an endophytic fungus isolated from Nothapodytes foetida.
- Authors
Rehman, Suriya; Shawl, Abdul; Sultana, Sarvat; Kour, Amardeep; Riyaz-ul-Hassan, Syed; Qazi, Ghulam
- Abstract
An attempt has been made to assess in vitro cytotoxicity of an endophytic fungus from Nothapodytes foetida. Various human cancer cell lines (liver HEP-2, lung A-549, ovary OVAR-5, prostate PC-3, cervix Hela, colon HCT-15, oral cell line KB, CNS SNB-78, were used. In vitro cytotoxicity of camptothecin (CPT) isolated from the fungus was done where OVAR-5 cell line showed maximum inhibition and HEP-2 cell line was least sensitive with this compound. In vitro cytotoxicity of fractions/extracts from endophyte was carried out where ethyl acetate fraction showed sufficient growth inhibition against all the cell lines.
- Publication
Annals of Microbiology, 2009, Vol 59, Issue 1, p157
- ISSN
1590-4261
- Publication type
Article
- DOI
10.1007/BF03175614