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- Title
Obesity-Related Hormone.
- Authors
Stephenson, Joan
- Abstract
The article reports that a brain chemical mutation called Β-melanocyte-stimulating hormone (Β-MSH) increases the risk for severe obesity in childhood. Obese children were more likely to carry the mutation than their normal-sized relatives or the rest of the normal-sized population. The mutation interferes with the hormone's ability to stimulate melanocortin-4 receptor, which controls energy balance. Research on children with the Β-MSH mutation and animals injected with it do not reduce their food intake. There is research into drugs that simulate the effects of appetite suppressing α-MSH.
- Subjects
MSH (Hormone); CHILDHOOD obesity; NUTRITION disorders; GENETIC mutation; HORMONE receptors; BODY weight; APPETITE depressants
- Publication
JAMA: Journal of the American Medical Association, 2006, Vol 295, Issue 11, p1239
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.295.11.1239-d