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- Title
Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection.
- Authors
Straus, Stephen E.; Tosato, Giovanna; Armstrong, Gary; Lawley, Thomas; Preble, Olivia T.; Henle, Werner; Pearson, Gary; Brus, Irena; Blaese, Michael; Straus, S E; Tosato, G; Armstrong, G; Lawley, T; Preble, O T; Henle, W; Davey, R; Pearson, G; Epstein, J; Brus, I
- Abstract
Clinical, serologic, virologic, and immunologic evaluations for 31 adults with chronic illness and fatigue suggested that 23 had persisting Epstein-Barr virus infection. Among these 23 patients, cellular immune mechanisms were generally normal, but 4 had mild immunoglobulin deficiencies. However, 20 patients had abnormal serologic profiles specific for Epstein-Barr virus shown by significantly elevated titers of antibodies to the viral capsid antigen or early antigen, or by a deficiency of late-appearing antibodies. In 11 of 15 patients tested, circulating immune complexes were found. Circulating interferon was not found in 18 patients tested, but the activity of 2-5 oligoadenylate synthetase, an interferon-induced enzyme, was increased in 5 patients studied. Of 19 patients, 18 had persisting suppressor T-cell activity typically found in patients recovering from acute infectious mononucleosis. We believe that the Epstein-Barr virus may be associated with chronic illness in adults.
- Subjects
FATIGUE (Physiology); EPSTEIN-Barr virus; CHRONIC diseases
- Publication
Annals of Internal Medicine, 1985, Vol 102, Issue 1, p7
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-102-1-7