We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
La infección por virus del papiloma humano afecta el pronóstico del cáncer orofaríngeo escamocelular. Revisión de la literatura.
- Authors
González Díaz, Melissa; Moreno Torres, Andrey; Chala Galindo, Andrés Ignacio; Tupaz Erira, Herlinto Alveiro; García Robayo, Dabeiba Adriana
- Abstract
Background: Squamous cell cancer of the head and neck can be caused mainly by high cigarette and alcohol consumption. However, about 30% of tumors can be caused by infection with human papillomavirus (HPV) mainly in the oropharynx. In the last decade, the frequency of this tumor has increased worldwide. Purpose: To analyze the characteristics and differences of oropharyngeal tumors associated or not with HPV infection. Methods: A review of the literature on the association between HPV, oropharyngeal squamous cell cancer, and its prognosis was performed. Findings: HPV is an oncogenic virus. It is estimated that about 40 HPV types can infect humans, of which 14 are directly related to carcinogenic processes. Several studies show that the HPV 16 genotype occurs more frequently and aggressively than other HPV genotypes associated with this type of tumor. Oropharynx cancer has a higher prevalence in males, possibly related to practices such as oral sex. Recently, a better prognosis for HPV-positive tumors has been observed when compared to negative tumors. This is because the former have a better response to chemotherapy and radiation, which results in a favorable overall survival rate (p=0.046, log-rank), as estimated through Kaplan-Meier curves.
- Publication
Universitas Odontológica, 2014, Vol 33, Issue 71, p67
- ISSN
0120-4319
- Publication type
Article
- DOI
10.11144/Javeriana.uo33-71.ivph