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- Title
Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study.
- Authors
Tanghöj, Gustaf; Liuba, Petru; Sjöberg, Gunnar; Naumburg, Estelle
- Abstract
<bold>Introduction: </bold>Secundum atrial septal defect is one of the most common congenital heart defects. Previous paediatric studies have mainly addressed echocardiographic and few clinical factors among children associated with adverse events. The aim of this study was to identify neonatal and other clinical risk factors associated with adverse events up to one year after closure of atrial septal defect.<bold>Methods: </bold>This retrospective case-control study includes children born in Sweden between 2000 and 2014 that were treated surgically or percutaneously for an atrial septal defect. Conditional logistic regression was used to evaluate the association between major and minor adverse events and potential risk factors, adjusting for confounding factors including prematurity, neonatal sepsis, neonatal general ventilatory support, symptomatic atrial septal defects, and pulmonary hypertension.<bold>Results: </bold>Overall, 396 children with 400 atrial septal defect closures were included. The median body weight at closure was 14.5 (3.5-110) kg, and the median age was 3.0 (0.1-17.8) years. Overall, 110 minor adverse events and 68 major events were recorded in 87 and 49 children, respectively. Only symptomatic atrial septal defects were associated with both minor (odds ratio (OR) = 2.18, confidence interval (CI) 95% 1.05-8.06) and major (OR = 2.80 CI 95% 1.23-6.37) adverse events.<bold>Conclusion: </bold>There was no association between the investigated neonatal comorbidities and major or minor events after atrial septal defect closure. Patients with symptomatic atrial septal defects had a two to four times increased risk of having a major event, suggesting careful management and follow-up of these children prior to and after closure.
- Subjects
SWEDEN; NEONATAL diseases; CONGENITAL heart disease; ATRIAL septal defects; NEONATAL sepsis; RETROSPECTIVE studies; ODDS ratio; PULMONARY hypertension; CARDIAC catheterization; RESEARCH; PREMATURE infants; TIME; RESEARCH methodology; SURGICAL complications; EVALUATION research; MEDICAL cooperation; TREATMENT effectiveness; COMPARATIVE studies; LOGISTIC regression analysis; COMORBIDITY; LONGITUDINAL method
- Publication
Cardiology in the Young, 2020, Vol 30, Issue 3, p303
- ISSN
1047-9511
- Publication type
journal article
- DOI
10.1017/S1047951119002919