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- Title
Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified.
- Authors
Kawamoto, Keisuke; Miyoshi, Hiroaki; Yanagida, Eriko; Yoshida, Noriaki; Kiyasu, Junichi; Kozai, Yasuji; Morikita, Tatsuma; Kato, Takeharu; Suzushima, Hitoshi; Tamura, Shinobu; Muta, Tsuyoshi; Kato, Koji; Eto, Tetsuya; Seki, Ritsuko; Nagafuji, Koji; Sone, Hirohito; Takizawa, Jun; Seto, Masao; Ohshima, Koichi
- Abstract
Objectives T-cell prolymphocytic leukemia (T- PLL) is a very rare, aggressive T-cell neoplasm. Peripheral T-cell lymphoma, not otherwise specified ( PTCL- NOS) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T- PLL and PTCL- NOS. Methods We analyzed 15 T- PLL and 91 PTCL- NOS patients and also compared clinical features between T- PLL and PTCL- NOS with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared. Results T-PLL cells were smaller in size than those of PTCL- NOS with leukemic presentation ( P=.0068); moreover, PTCL- NOS cells with leukemic presentation were smaller than those of PTCL- NOS without leukemic presentation ( P=.0017). Immunophenotypic patterns in T- PLL and PTCL- NOS were similar. Five-year overall survival rates of T- PLL and all PTCL- NOS patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T- PLL and PTCL- NOS with leukemic presentation had essentially equivalent characteristics. Conclusion T-PLL and PTCL- NOS may share common biological and clinical characteristics in Japanese patients.
- Subjects
LYMPHOCYTIC leukemia; T cells; IMMUNOPHENOTYPING; CLINICAL pathology; SURVIVAL analysis (Biometry); JAPANESE people; TUMORS; HEALTH
- Publication
European Journal of Haematology, 2017, Vol 98, Issue 5, p459
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.12856