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- Title
Interleukin-6 signaling pathway involved in major depressive disorder: selective serotonin reuptake inhibitor regulates IL-6 pathway.
- Authors
Askari, Marziye; Jahangard, Leila; Zamani, Alireza; Haghighi, Mohammad; Salehi, Iraj; Zareighane, Zohre; Solgi, Ghasem; Shahbazi, Reza; Alahgholi-Hajibehzad, Mahdi
- Abstract
Background: Evidence indicates that pro-inflammatory Th17 and Th1 cells are involved in major depressive disorder (MDD) pathogenesis. Development of Th17 and Th1 are regulated by IL-6 and IFN-γ, respectively. In this study, the levels of IL-6 and IFN-γ, and mRNA expression of related signaling components and, Th17/Th1 transcription factors were investigated in MDD patients with/without selective serotonin reuptake inhibitor (SSRI) medication. Materials and methods: Forty-six patients and 38 healthy controls (HCs) were recruited. Twenty patients were received the SSRI (sertraline 50-200 mg/day) for at least 1 year, and 26 patients were not received medication. Expression of IL-6R, IFN-γR, JAK1, JAK2, TYK2, STAT1, STAT3, T-bet and RORγt were assessed with Real-Time-PCR. Serum and supernatant levels of IL-6 and IFN-γ were determined using ELISA. Results and discussion: The serum and supernatant levels of IL-6 were increased in patients without (SSRI-) compared with HCs, while its levels was reduced in SSRI+. Elevated expressions of IL-6R, STAT3 and RORγt were observed in SSRI-compared with HCs. Expressions of IL-6R, STAT3, RORγt and IFN-γR, were decreased in SSRI+ compared to SSRI- patients. Conclusion: Increased IL-6 involved in MDD, and SSRI regulates IL-6 pathway and IL-6 production. MDD patients may benefit from IL-6/IL-6R targeted therapeutic intervention.
- Subjects
SEROTONIN uptake inhibitors; MENTAL depression; INTERLEUKIN-6; T helper cells; TH1 cells
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2019, Vol 44, Issue 6, p831
- ISSN
0250-4685
- Publication type
Article
- DOI
10.1515/tjb-2019-0010