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- Title
Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment.
- Authors
Ammerman, Nicole C; Nuermberger, Eric L; Owen, Andrew; Rannard, Steve P; Meyers, Caren Freel; Swindells, Susan
- Abstract
A key component of global tuberculosis (TB) control is the treatment of latent TB infection. The use of long-acting technologies to administer TB preventive treatment has the potential to significantly improve the delivery and impact of this important public health intervention. For example, an ideal long-acting treatment could consist of a single dose that could be administered in the clinic (ie, a "1-shot cure" for latent TB). Interest in long-acting formulations for TB preventive therapy has gained considerable traction in recent years. This article presents an overview of the specific considerations and current preclinical advancements relevant for the development of long-acting technologies of TB drugs for treatment of latent infection, including attributes of target product profiles, suitability of drugs for long-acting formulations, ongoing research efforts, and translation to clinical studies.
- Subjects
TUBERCULOSIS prevention; DRUG delivery systems; CLINICAL drug trials; PUBLIC health; PREVENTIVE health services; ANTITUBERCULAR agents; DRUG development; PHARMACEUTICAL chemistry
- Publication
Clinical Infectious Diseases, 2022, Vol 75, pS510
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac672