We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neutralizing Antibody Responses to Homologous and Heterologous H1 and H3 Influenza A Strains After Vaccination With Inactivated Trivalent Influenza Vaccine Vary With Age and Prior-year Vaccination.
- Authors
Wang, Wei; Chen, Qiong; Ford-Siltz, Lauren A; Katzelnick, Leah C; Parra, Gabriel I; Song, Hyo Sook; Vassell, Russell; Weiss, Carol D
- Abstract
Background Prior influenza immunity influences the homologous neutralizing antibody responses elicited by inactivated influenza vaccines (IIV), but neutralizing antibody responses to heterologous strains have not been extensively characterized. Methods We analyzed neutralizing antibody titers in individuals aged 1–88 who received the 2009–2010 season IIV before infection by or vaccination against the 2009 pandemic H1N1 virus. Neutralization titers to homologous and heterologous past, recent, and advanced H1 and H3 strains, as well as H2, H5, and H7 strains, were measured using influenza hemagglutinin pseudoviruses. We performed exploratory analyses based on age, prior-year IIV, and prevaccination titer, without controlling for Type I errors. Results IIV elicited neutralizing antibodies to past and advanced H1 and H3 strains, as well as to an H2 strain in individuals who were likely infected early in life. The neutralization of avian subtype viruses was rare, and there was no imprinting of neutralization responses to novel avian subtype viruses based on the influenza group. Compared to adults, children had higher seroresponse rates to homologous and heterologous strains, and their sera generated larger antigenic distances among strains. Seroresponse rates to homologous and heterologous strains were lower in subjects vaccinated with prior-year IIV, though postimmunization titers were generally high. Conclusions IIV elicited neutralizing antibodies to heterologous H1 and H3 strains in all ages groups, but titers and seroresponse rates were usually higher in children. Prior-year vaccination with the same strains tended to blunt IIV neutralization responses to all strains in young and old age groups, yet postimmunization titers were high.
- Subjects
H1N1 influenza; INFLUENZA vaccines; IMMUNOGLOBULIN analysis; AGE distribution; IMMUNIZATION; IMMUNOLOGICAL adjuvants; RESEARCH; SERODIAGNOSIS; INFLUENZA A virus, H1N1 subtype; PREVENTION; VACCINATION; THERAPEUTICS
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 12, p2067
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy818