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- Title
Whey protein positively alters inflammatory markers and metabolic parameters of overweight and obese adults.
- Authors
Chanchira Phosat; Charupan Phosat; Chatrapa Hudthagosol; Pornpimo Panprathip Phienluphon; Karunee Kwanbunjan
- Abstract
Introduction: The effects of prolonged consumption of whey protein on health are controversial. This study aimed to determine whether whey protein positively alters health parameters of overweight and obese adults. Methods: Randomised controlled trial was conducted. Fifty-eight participants, aged 30-50 years, were randomly allocated into four groups and supplemented with 50 g protein for eight weeks (group 1: plant-based protein (PBP), group 2: whey protein isolate (WPI) with cocoa powder, group 3: PBP with whey protein concentrate (WPC), and group 4: WPI with milk powder). Body composition and biochemical parameters (kidney and liver functions, inflammation, oxidative stress, and antioxidant capacity) were evaluated at pre-intervention and 8 weeks after intervention. Results: At Week 8, group 3 had lower diastolic blood pressure, waist circumference, visceral fat, and risk of insulin resistance (p<0.05 for all). Group 2 had decreased levels of total cholesterol and low-density lipoprotein cholesterol (p<0.05 for all). A drop in triglyceride was seen in group 4 (p=0.026). Whey protein decreased alanine aminotransferase level (p=0.028), while PBP increased aspartate aminotransferase level (p=0.034). PBP or WPI with milk powder increased blood urea nitrogen level (p>0.05 for all). Interleukin-6 and lactoferrin levels fell in all groups (p<0.05), while hs-CRP increased in the PBP group (p=0.043). Group 2 experienced increased antioxidant capacity. However, levels of oxidative stress markers were significantly decreased in the PBP group and WPI with milk powder group. Conclusion: Whey protein revealed positive effects on anthropometric parameters and biochemical markers of overweight and obese adults. Therefore, proper supplementation of whey protein can potentially promote health.
- Subjects
INSULIN resistance risk factors; ANALYSIS of triglycerides; GLYCOPROTEIN analysis; REDUCING diets; BODY composition; BIOCHEMISTRY; INTERLEUKINS; C-reactive protein; BLOOD urea nitrogen; CACAO; LDL cholesterol; ANTIOXIDANTS; TREATMENT effectiveness; RANDOMIZED controlled trials; DIETARY supplements; DIASTOLIC blood pressure; PLANT proteins; WAIST circumference; RESEARCH funding; INFLAMMATORY mediators; WHEY proteins; STATISTICAL sampling; POWDERS; ADIPOSE tissues; CHOLESTEROL; ALANINE aminotransferase; ASPARTATE aminotransferase; PHARMACODYNAMICS
- Publication
Malaysian Journal of Nutrition, 2022, Vol 28, Issue 3, p369
- ISSN
1394-035X
- Publication type
Article
- DOI
10.31246/mjn-2021-0100