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- Title
miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells
- Authors
Li, Jipeng; Wang, Yiping; Luo, Jianping; Fu, Zhongming; Ying, Jianfei; Yu, Yanhong; Yu, Wanjun
- Abstract
Abstract: Recent studies have implied that miRNAs act as crucial modulators for epithelial-to-mesenchymal transition (EMT). We found that miR-134 expression correlated with invasive potential and EMT phenotype of NSCLC cells. Functional assays demonstrated that miR-134 inhibited EMT in NSCLC cells. In addition, we showed that Forkhead Box M1 (FOXM1) is a direct target of miR-134. Knockdown of FOXM1 reversed EMT resembling that of miR-134 overexpression. We further found that FOXM1 was involved in TGF-β1-induced EMT in A549 cells. These findings suggest that miR-134 acts as a novel EMT suppressor in NSCLC cells.
- Subjects
MICRORNA; EPITHELIAL cells; MESENCHYMAL stem cells; LUNG cancer; CANCER cells; PHENOTYPES
- Publication
FEBS Letters, 2012, Vol 586, Issue 20, p3761
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.09.016