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- Title
MicroRNA-451 regulates p38 MAPK signaling by targeting of Ywhaz and suppresses the mesangial hypertrophy in early diabetic nephropathy
- Authors
Zhang, Zheng; Luo, Xiaomei; Ding, Songtao; Chen, Junxia; Chen, Tao; Chen, Xin; Zha, He; Yao, Li; He, Xiaoyan; Peng, Huimin
- Abstract
Abstract: Diabetic nephropathy (DN) is a major diabetic complication. However, the initiating molecular events triggering DN are unknown. In this study we focused on microRNA-451 (miR-451), which is downregulated during early DN. We found that miR-451 negatively regulated the expression of Ywhaz through Ywhaz 3′UTR and that Ywhaz was required for the miR-451-mediated downregulation of p38 MAPK signalling. Moreover, over-expression of miR-451 inhibits glomerular mesangial cell proliferation in vitro and in vivo. These findings suggest that the growth-inhibitory effect of miR-451 may be explained in part by miR-451-induced suppression of Ywhaz and p38 MAPK signalling, providing evidence for the potential role of miR-451 in early DN.
- Subjects
MICRORNA; HYPERTROPHY; DIABETIC nephropathies; DIABETES complications; MITOGEN-activated protein kinases; ENZYME analysis; CELL proliferation
- Publication
FEBS Letters, 2012, Vol 586, Issue 1, p20
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.07.042