We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer.
- Authors
Xiao-Chun, Wang; Wei, Wang; Zhu-Bo, Zhang; Jing, Zhao; Xiao-Gang, Tan; Jian-Chao, Luo; Wang, Xiao-chun; Wang, Wei; Zhang, Zhu-Bo; Zhao, Jing; Tan, Xiao-Gang; Luo, Jian-Chao
- Abstract
<bold>Background: </bold>MiRNA-21 was previously reported to be up-regulated in many kinds of cancer. In the present study, we want to investigate the potential role of miRNA-21 in non-small cell lung cancer.<bold>Materials and Methods: </bold>Expression of miRNA-21 was detected in 60 non-small cell lung cancer (NSCLC) samples and adjacent histologically normal tissue using RT-qPCR, Correlation between miRNA-21 expression and clinicopathological features of NSCLC was analyzed using statistical software. The effect of miRNA-21 expression on the growth and apoptosis of A549 cells induced by irradiation was examined.<bold>Results: </bold>miRNA-21 expression increased in non-small cell lung cancer. Expression of miRNA-21 was positively associated with lymph node metastasis, clinical stage and poor prognosis. Multivariate Cox regression analysis showed that miRNA-21 was an independent prognostic factor for patients. Down-regulation of miRNA-21 inhibited proliferation and cell cycle progress of A549 cells and sensitized cells to radiation. Decreased miRNA-21 expression promoted the apoptosis of A549 cells induced by irradiation.<bold>Conclusions: </bold>miRNA-21 may be considered as a potential novel target for future development of specific therapeutic interventions in NSCLC.
- Publication
Radiation Oncology, 2013, Vol 8, Issue 1, p146
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/1748-717X-8-146