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- Title
Single dose and repeated administrations of liraglutide alter energy metabolism in the brains of young and adult rats.
- Authors
Prá, Morgana; Ferreira, Gabriela Kozuchovski; de Mello, Aline Haas; Schraiber, Rosiane de Bona; Cardoso, Larissa Colonetti; Souza, Luana da Rosa; da Rosa, Naiana; Fortunato, Jucélia Jeremias; Rezin, Gislaine Tezza
- Abstract
Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 μg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.
- Subjects
BRAIN metabolism; ENERGY metabolism; GLUCAGON-like peptide 1; CREATINE kinase; PREFRONTAL cortex; HIPPOCAMPUS (Brain)
- Publication
Biochemistry & Cell Biology, 2016, Vol 94, Issue 5, p451
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/bcb-2016-0016