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- Title
Furazolidone-based Therapies for Helicobacter pylori Infection: A Pooled-data Analysis.
- Authors
Zullo, Angelo; Ierardi, Enzo; Hassan, Cesare; De Francesco, Vincenzo
- Abstract
Background/Aim: Furazolidone-based therapies are used in developing countries to cure Helicobacter pylori infection due to its low cost. The low bacterial resistance toward furazolidone may render appealing the use of this drug even in developed countries. However, some relevant safety concerns do exist in using furazolidone. Patients and Methods: This was a systematic review with pooled-data analysis of data regarding both eradication rate and safety of furazolidone-based therapies for H. pylori infection. Intention-to-treat (ITT) and per-protocol (PP) eradication rates were calculated. Results: Following furazolidone-based first-line therapy, H. pylori eradication rates were 75.7% and 79.6% at ITT and PP analysis, respectively (P<0.001). The overall incidence of side effects and severe side effects were 33.2% and 3.8%, respectively. At multivariate analysis, only high-dose furazolidone was associated with increased therapeutic success (OR: 1.5, 95% CI: 1.3-2.7; P<0.001), while occurrence of side effects was relevant following treatment for a long duration (OR: 2.9, 95% CI: 2.2-4.1; P<0.001), high-dose furazolidone (OR: 2.3, 95% CI: 1.7-3.2; P<0.001) and bismuth-containing regimens (OR: 2.1, 95% CI: 1.5-2.8; P<0.001). Conclusions: Furazolidone-based regimens usually achieve low eradication rates. Only a high-dose regimen improves the cure rate, but simultaneously increases the incidence of severe side effects. Therefore, we suggest that patients have to be clearly informed about the possible genotoxic and carcinogenetic effects for which furazolidone use is not approved in developed countries.
- Subjects
ANTIBIOTICS; CHI-squared test; CONFIDENCE intervals; DRUG resistance; EPIDEMIOLOGY; FISHER exact test; HELICOBACTER diseases; MEDLINE; MONOAMINE oxidase inhibitors; MULTIVARIATE analysis; GENETIC mutation; ONLINE information services; PATIENT education; TUMORS; LOGISTIC regression analysis; DATA analysis; DATA analysis software; THERAPEUTICS
- Publication
Saudi Journal of Gastroenterology, 2012, Vol 18, Issue 1, p11
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.91729