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- Title
Polymorphisms in the Matrilin-1 Gene and Risk of Mandibular Prognathism in Koreans.
- Authors
Jang, J.Y.; Park, E.K.; Ryoo, H.M.; Shin, H.I.; Kim, T.H.; Jang, J.S.; Park, H.S.; Choi, J.Y.; Kwon, T.G.
- Abstract
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19~197.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05~0.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03~13.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism.
- Publication
Journal of Dental Research, 2010, Vol 89, Issue 11, p1203
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/0022034510375962