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- Title
Effectiveness of incorporating cetuximab into docetaxel/cisplatin/fluorouracil induction chemotherapy and chemoradiotherapy for inoperable squamous cell carcinoma of the oral cavity: A phase II study.
- Authors
Chang, Peter Mu‐Hsin; Lu, Hsueh‐Ju; Wang, Ling‐Wei; Tai, Shyh‐Kuan; Chen, Ming‐Huang; Chu, Pen‐Yuan; Yang, Muh‐Hwa
- Abstract
Background Inoperable oral cavity squamous cell carcinoma (SCC) is a highly invasive disease associated with the extensive destruction of locoregional tissues and a dismal prognosis. Management strategies for these patients are limited. Methods This study was a single arm, prospective, open-label phase II trial. A regimen consisting of cetuximab-docetaxel, cisplatin, and fluorouracil (C-TPF) followed by bio-chemoradiotherapy (bio-CRT) with cisplatin and cetuximab was administered to patients who responded to induction chemotherapy. The objective response rate to C-TPF was the primary endpoint. Results Forty-three patients were enrolled in this study. The objective response rate of C-TPF was 88.4%; 88.9% (32/36) of the responders completed the full bio-CRT course, and the objective response rate of bio-CRT was 64.7%. The most common grade 3/4 adverse events for induction chemotherapy were leucopenia (32.6%) and febrile neutropenia (14.0%). The 1-year progression-free survival (PFS) and overall survival (OS) rates were 43% and 68%, respectively. Conclusion C-TPF is an effective and tolerable induction chemotherapy regimen for inoperable oral cavity SCC.
- Subjects
SQUAMOUS cell carcinoma; CANCER chemotherapy; CHEMORADIOTHERAPY; CETUXIMAB; PROGNOSIS; THERAPEUTICS
- Publication
Head & Neck, 2017, Vol 39, Issue 7, p1333
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24766