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- Title
Cyclooxygenase-2 Expression and Prostaglandin E<sub>2</sub> Production in Response to Acidic pH Through OGR1 in a Human Osteoblastic Cell Line.
- Authors
Tomura, Hideaki; Ju-Qiang Wang; Jin-Peng Liu; Komachi, Mayumi; Damirin, Alatangaole; Mogi, Chihiro; Tobo, Masayuki; Nochi, Hiromi; Tamoto, Koichi; Doon-Soon Im; Sato, Koichi; Okajima, Fumikazu
- Abstract
The article discusses cyclooxygenase-2 expression and prostaglandin E2 production that is induced by extracellular acidification in a human osteoblastic cell line. The study suggests that small interfering RNA inhibited this induced response when the ovarian cancer G protein-coupled receptor 1 (OGR1) and inhibitors of intracellular signaling were targeted.
- Subjects
CYCLOOXYGENASE 2; ACIDOSIS; PROSTAGLANDINS E; SMALL interfering RNA
- Publication
Journal of Bone & Mineral Research, 2008, Vol 23, Issue 7, p1129
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/jbmr.080236