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- Title
Numerical Simulation of Bone Regeneration in a Bone Chamber.
- Authors
Geris, L.; Vandamme, K.; Naert, I.; Vander Sloten, J.; Duyck, J.; Van Oosterwyck, H.
- Abstract
While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains uninvestigated. We tested the hypothesis that a mechano-regulatory model has the potential to predict bone regeneration around implants. In an in vivo bone chamber set-up allowing for controlled implant loading (up to 90 µm axial displacement), bone tissue formation was simulated and compared qualitatively and quantitatively with histology. Furthermore, the model was applied to simulate excessive loading conditions. Corresponding to literature data, implant displacement magnitudes larger than 90 µm predicted the formation of fibrous tissue encapsulation of the implant. In contradiction to findings in orthopedic implant osseointegration, implant displacement frequencies higher than 1 Hz did not favor the formation of peri-implant bone in the chamber. Additional bone chamber experiments are needed to test these numerical predictions.
- Subjects
BONE regeneration; TISSUE differentiation; FINITE element method; BONE growth; DENTURES; DENTISTRY
- Publication
Journal of Dental Research, 2009, Vol 88, Issue 2, p158
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/0022034508329603