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- Title
Role of C-Peptide in the Regulation of Microvascular Blood Flow.
- Authors
Forst, T.; Kunt, T.; Wilhelm, B.; Weber, M. M.; Pfützner, A.
- Abstract
During the recent years, the role of C-peptide, released from the pancreatic beta cell, in regulating microvascular blood flow, has received increasing attention. In type 1 diabetic patients, intravenous application of C-peptide in physiological concentrations was shown to increase microvascular blood flow, and to improve microvascular endothelial function and the endothelial release of NO. C-peptide was shown to impact microvascular blood flow by several interactive pathways, like stimulating Na+K+ATPase or the endothelial release of NO. There is increasing evidence, that in patients with declining beta cell function, the lack of C-peptide secretion might play a putative role in the development of microvascular blood flow abnormalities, which go beyond the effects of declining insulin secretion or increased blood glucose levels.
- Subjects
C-peptide; MICROCIRCULATION disorders; PANCREATIC beta cells; BLOOD sugar; DIABETES; THERAPEUTICS
- Publication
Experimental Diabetes Research, 2009, p1
- ISSN
1687-5214
- Publication type
Article
- DOI
10.1155/2008/176245