We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impaired Limbic Gamma Oscillatory Synchrony during Anxiety-Related Behavior in a Genetic Mouse Model of Bipolar Mania.
- Authors
Dzirasa, Kafui; McGarity, DeAnna L.; Bhattacharya, Anirban; Kumar, Sunil; Takahashi, Joseph S.; Dunson 6, David; McClung, Colleen A.; Nicolelis, Miguel A. L.
- Abstract
Alterations in anxiety-related processing are observed across many neuropsychiatric disorders, including bipolar disorder. Though polymorphisms in a number of circadian genes confer risk for this disorder, little is known about how changes in circadian gene function disrupt brain circuits critical for anxiety-related processing. Here we characterize neurophysiological activity simultaneously across five limbic brain areas (nucleus accumbens, amygdala, prelimbic cortex, ventral hippocampus, and ventral tegmental area) as wild-type (WT) mice and mice with a mutation in the circadian gene, CLOCK (Clock-Δ19 mice) perform an elevated zero maze task. In WT mice, basal limbic gamma oscillatory synchrony observed before task performance predicted future anxiety-related behaviors. Additionally, dynamic changes in limbicgammaoscillatory synchrony were observed based on the position ofWTmice in the zero maze. Clock-Δ19 mice, which displayed an increased propensity to enter the open section of the elevated maze, showed profound deficits in these anxiety-related circuit processes. Thus, our findings link the anxiety-related behavioral deficits observed in Clock-Δ19mice with dysfunctional gamma oscillatory tuning across limbic circuits and suggest that alterations in limbic oscillatory circuit function induced by circadian gene polymorphisms may contribute to the behavioral manifestations seen in bipolar mania.
- Subjects
NEUROBEHAVIORAL disorders; BIPOLAR disorder; ANXIETY disorders; ANXIETY; CIRCADIAN rhythms; MICE behavior; LABORATORY mice; GENETICS
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 17, p6449
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.6144-10.2011