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- Title
HIV-1 RNA Kinetics in Blood Plasma and in Seminal Plasma of Men Starting a Dolutegravir-Based Triple-Combination Regimen at the Time of Primary HIV-1 Infection.
- Authors
Ghosn, Jade; Assoumou, Lambert; Lascoux-Combe, Caroline; Peytavin, Gilles; Amat, Karine; Gabassi, Audrey; Le, Minh P; Nzalakanda, Robert; Valin, Nadia; Landman, Roland; Chaix, Marie-Laure; Delaugerre, Constance
- Abstract
We compared the proportion of participants achieving first undetectable HIV-1 RNA (VL) in seminal plasma (SP) and blood plasma (BP) in 19 men starting dolutegravir-based regimen at primary HIV infection. At baseline, median VL was 6.5 (interquartile range [IQR], 5.6-7.9) and 4.5 (IQR, 3.5-5.0) log10 copies/mL in BP and SP, respectively. Between baseline and week 48, significantly higher proportion of participants achieved first VL below limit of quantification in SP (93.0%) than in BP (84.2%; P = .008). Time to first undetectable VL was 8 weeks in SP (95% confidence interval [CI], 5.6-10.4) and 24 weeks in BP (95% CI, 14.1-33.9).
- Subjects
BLOOD plasma; INFECTION; HIV; HIV infections; RNA; PYRIDINE; ANTI-HIV agents; RESEARCH; SEMEN; HETEROCYCLIC compounds; VIRAL load; RESEARCH methodology; EVALUATION research; DYNAMICS; COMPARATIVE studies
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 1, p116
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab336