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- Title
Granzyme B production by Th2 helper and NK cells improves the LTT test in patients with non‐immediate drug hypersensitivity reactions.
- Authors
Blom, Lars H.; Schmidt, Lasse B.; Johnsen, Claus R.; Elberling, Jesper; Poulsen, Lars K.; Garvey, Lene H.
- Abstract
This article discusses the use of a flow cytometry version of the lymphocyte transformation test (LTT) as a potential alternative to intradermal tests (IDT) and drug provocation tests (DPT) for diagnosing non-immediate drug hypersensitivity reactions (NIDHRs). The study found that stimulation with culprit drugs produced a higher stimulation index (SI) of drug-specific cells in patients who tested positive on IDT compared to those who tested negative. The study also found that culprit-reactive Th2 helper and NK cells showed cytolytic activity and produced granzyme B, indicating an inflammatory phenotype. The results suggest that analyzing drug-specific cytokine production by Th and NK cells could be a promising method for predicting in vivo skin reactivity to drugs and could potentially be used as a supplement or alternative to IDT for diagnosing NIDHRs.
- Subjects
TH2 cells; DRUG allergy; GRANZYMES; PEANUT allergy; KILLER cells
- Publication
Allergy, 2024, Vol 79, Issue 2, p520
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15936