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- Title
The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients.
- Authors
Yang, L. Q.; Tao, K. M.; Cheung, C. W.; Liu, Y. T.; Tao, Y.; Wu, F. X.; Yu, W. F.
- Abstract
This study compared the effect of isoflurane or propofol anaesthesia on postoperative hepatocellular injury, liver function and pro-inflammatory cytokine concentrations in 60 cirrhotic patients, after partial hepatectomy using Pringle's manoeuvre. In the isoflurane group postoperatively, both mean (SD) aspartate aminotransferase (day 1: 197 (123) U.l−1 vs 261 (143) U.l−1; p = 0.01; day 3: 465 (258) U.l−1 vs 578 (311) U.l−1; p = 0.02) and alanine aminotransferase (day 1: 575 (312) U.l−1 vs 714 (434) U.l−1; p = 0.04 and day 3: 776 (443) U.l−1 vs 898 (746) U.l−1; p = 0.03) were significantly lower compared with the propofol group. Mean (SD) postoperative white cell count was significantly lower with isoflurane than propofol (day 1: 12 (4) × 103.mm−1 vs 16 (4) × 103.mm−1; p = 0.01 and day 3: 10 (6) × 103.mm−1; vs 14 (4); p = 0.01). Tumour necrosis factor-α (day 1) and interleukin-1 (days 1 and 3) concentrations were significantly lower with isoflurane. Compared with propofol, isoflurane is associated with an attenuated postoperative inflammatory response and less postoperative hepatocellular injury in patients having this procedure.
- Subjects
ISOFLURANE; PROPOFOL; ANESTHETICS; PHARMACODYNAMICS; LIVER injuries; THERAPEUTICS; HEPATECTOMY; ASPARTATE aminotransferase; ALANINE aminotransferase
- Publication
Anaesthesia, 2010, Vol 65, Issue 11, p1094
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2010.06505.x