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- Title
Initial evaluation of the use of USPIO cell labeling and noninvasive MR monitoring of human tissue-engineered vascular grafts in vivo.
- Authors
Nelson, G. N.; Roh, J. D.; Mirensky, T. L.; Wang, Y.; Yi, T.; Tellides, G.; Pober, J. S.; Shkarin, P.; Shapiro, E. M.; Saltzman, W. M.; Papademetris, X.; Fahmy, T. M.; Breuer, C. K.
- Abstract
This pilot study examines noninvasive MR monitoring of tissue-engineered vascular grafts (TEVGs) in vivo using cells labeled with iron oxide nanoparticles. Human aortic smooth muscle cells (hASMCs) were labeled with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. The labeled hASMCs, along with human aortic endothelial cells, were incorporated into eight TEVGs and were then surgically implanted as aortic interposition grafts in a C.B-17 SCID/bg mouse host. USPIO-labeled hASMCs persisted in the grafts throughout a 3 wk observation period and allowed noninvasive MR imaging of the human TEVGs for real-time, serial monitoring of hASMC retention. This study demonstrates the feasibility of applying noninvasive imaging techniques for evaluation of in vivo TEVG performance.
- Subjects
IRON oxides; CELLS; VASCULAR grafts; MUSCLE cells; MEDICAL imaging systems
- Publication
FASEB Journal, 2008, Vol 22, Issue 11, p3888
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.08-107367