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- Title
Two-color flow cytometry analysis of activated T-lymphocyte subsets in type I diabetes mellitus.
- Authors
Legendre, Christoph M.; Schiffrin, Alicia; Weitzner, Gabriel; Colle, Eleanor; Guttmann, Ronald D.; Legendre, C M; Schiffrin, A; Weitzner, G; Colle, E; Guttmann, R D
- Abstract
We addressed the question of whether newly diagnosed type I (insulin-dependent) diabetes mellitus patients showed an increased number of DR (la+) T-lymphocytes compared with nondiabetic siblings and normal control subjects. Two-color flow cytometry measurements of peripheral-blood lymphocytes showed a slight but statistically significant increase in DR+ T-lymphocytes in diabetic subjects as well as the nondiabetic sibling control compared with the normal control subjects. This difference was not present in long-term-diabetic subjects. Thus, in addition to minor changes in this lymphocyte subset in peripheral blood, the sibling data demonstrate a lack of specificity for the disease; therefore, these measurements are probably of limited diagnostic usefulness.
- Publication
Diabetes, 1988, Vol 37, Issue 6, p792
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.37.6.792