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- Title
(IMG04) The Association Between Magnetic Resonance Imaging Brain Volumes and Computerized Cognitive Scores of People with Multiple Sclerosis.
- Authors
Golan, Daniel; Srinivasan, Jared; Kaczmarek, Olivia; Bautista, Jonathan; Zarif, Myassar; Bumstead, Barbara; Buhse, Marijean; Fafard, Lori; Wilken, Jeffrey; Sullivan, Cynthia; Fratto, Timothy; Van Vlierberghe, Eline; Sima, Diana; Van Hecke, Wim; Gudesblatt, Mark
- Abstract
Background: Cognitive impairment is common and disabling among people with multiple sclerosis (PwMS) but is not often monitored or only partially screened due to complexity of evaluation. Computerized cognitive assessment facilitates the incorporation of multidomain cognitive monitoring into routine clinical follow-up. Objectives: To explore the associations between brain volumes and cognitive scores of a computerized cognitive assessment battery (CAB, NeuroTrax) among PwMS. Methods: Participants were tested with the CAB and underwent brain magnetic resonance imaging (MRI) within specified time intervals. The global cognitive score (GCS) is the average of age- and educationadjusted scores of the various cognitive domains (memory, information processing speed, attention, executive function, motor and verbal). Whole brain volume (WBV), gray matter volume (GMV), white matter volume (WMV), thalamic volume, hippocampal volume, white matter lesion volume, and lateral ventricles volume were assessed by IcoMetrix, a fully automated tissue and lesion segmentation and quantification software, that uses 3D T1-weighted and fluid-attenuated inversion recovery (FLAIR) MRIs. Results: 201 PwMS were tested with both CAB and MRI within 180 days (age: 52.3 ± 11.1, 143 [71%] female). Significant correlations were found between the GCS and WBV, WMV, GMV, thalamic volume, and FLAIR lesion volume (Spearman rhos: 0.33, 0.3, 0.43, 0.4, -0.26, P < .01, respectively). Correlation coefficients remained significant but decreased as the time between MRI and CAB increased. The number of impaired cognitive domains was also associated with both lesion volume and GMV (rho = 0.25, -0.44; P < .05, <.01, respectively). The only cognitive domain score that was associated with hippocampal volume was memory (rho = 0.27, P < .05). Conclusions: Computerized cognitive scores are significantly associated with quantified MRI. These findings demonstrate the added information that can be derived from integrating digital assessment tools into the routine clinical assessment of PwMS.
- Subjects
BRAIN anatomy; COGNITIVE testing; CONFERENCES &; conventions; MAGNETIC resonance imaging; MULTIPLE sclerosis; COMPUTER-aided diagnosis
- Publication
International Journal of MS Care, 2020, Vol 22, Issue S2, p48
- ISSN
1537-2073
- Publication type
Article