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- Title
Memantine was better than placebo in Alzheimer diseasealready being treated with donepezil.
- Authors
Hirsch, Calvin H.
- Abstract
This article investigates that treatment of patients with moderate to severe Alzheimer Disease (AD) with memantine was better than placebo. 404 patients ≥ 50 years of age (mean age 76 y, 65% women) with a diagnosis of probable AD, a mini-mental state examination score of 5 to 14, ongoing donepezil therapy for ≥ 6 months at a stable dose (5 to 10 mg/d) for≥ 3 months, a knowledgeable and reliable caregiver, ambulatory ability, and a stable medical condition were studied. Patients who received memantine had greater improvement than patients who received placebo in all cognitive, functional, and global outcome measures at 24 weeks.
- Subjects
ALZHEIMER'S disease; PLACEBOS; BEHAVIORAL medicine; DISEASES; SYMPTOMS; PATIENTS
- Publication
ACP Journal Club, 2004, Vol 141, Issue 2, p38
- ISSN
1056-8751
- Publication type
Article
- DOI
10.7326/acpjc-2004-141-2-038