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- Title
Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection.
- Authors
Mukherjee, A; Kumar, G; Turuk, A; Bhalla, A; Bingi, T C; Bhardwaj, P; Baruah, T D; Mukherjee, S; Talukdar, A; Ray, Y; John, M; Khambholja, J R; Patel, A H; Bhuniya, S; Joshi, R; Menon, G R; Sahu, D; Rao, V V; Bhargava, B; Panda, S
- Abstract
Objectives This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). Methods NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined. Results Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6–7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4–0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3–0.7)] were protected from in-hospital mortality. Conclusions WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.
- Subjects
INDIA; COVID-19; CHRONICALLY ill; VACCINATION; DATA collection platforms; CORONAVIRUS diseases; CHRONIC kidney failure; COUGH
- Publication
QJM: An International Journal of Medicine, 2023, Vol 116, Issue 1, p47
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcac202