We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acquired haemophilia A in paediatric patients: A retrospective French cohort of eight cases.
- Authors
Mouthon, Paul; Guy, Alexandre; d'Oiron, Roseline; Harroche, Annie; Lebreton, Aurélien; Gourguechon, Clément; Oudot‐Challard, Caroline; Huguenin, Yoann
- Abstract
Summary: Acquired haemophilia A (AHA) is a rare haemorrhagic disease characterised by new‐onset haemorrhagic symptoms associated with a dramatic decrease in factor VIII levels and an anti‐factor VIII neutralising autoantibody concentration >0.6 Bethesda units. Elderly people are often affected, whereas children are rarely affected; the paediatric incidence reported in the literature is about 0.045 case/million/year. For some time, the paediatric standard of care has been that for adults, but clinicians have often reported poor outcomes. Here, we describe the largest retrospective paediatric AHA cohort assembled to date, including eight patients diagnosed in France from 2000 to 2020.
- Subjects
BETHESDA (Md.); FRANCE; CHILD patients; HEMOPHILIA; HEMORRHAGIC diseases; BLOOD coagulation factor VIII antibodies; BLOOD coagulation factor VIII
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 2, p606
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19285