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- Title
The effect of bevacizumab for bone scintigraphy imaging: A case report.
- Authors
Takamitsu Asano; Osamu Takakuwa; Ken Maeno; Tetsuya Oguri; Akio Niimi; Asano, Takamitsu; Takakuwa, Osamu; Maeno, Ken; Oguri, Tetsuya; Niimi, Akio
- Abstract
A 65-year-old man presented with pulmonary nodules and a right humeral fracture. The 99mTc-hydroxy-methylene-diphosphonate (HMDP) bone scintigraphy showed high-intensity radioisotope (RI) uptake by a tumor of the right arm. Adenocarcinoma of the lung with an epidermal growth factor receptor (EGFR) mutation was diagnosed on pathological examination of the computed tomography (CT)-guided needle biopsy of the right humerus. Although, gefitinib therapy was initiated, the tumor progressed. The patient was then treated with second-line chemotherapy including bevacizumab. The CT scan showed a new bone metastasis in the ilium and right sacroiliac articulation. However, this new bone metastasis was not detected by HMDP-bone scintigraphy. Physicians should be wary of the interpretations of the findings of the 99mTc HMDP bone scintigraphy after the bevacizumab treatment.
- Subjects
BEVACIZUMAB; LUNG cancer diagnosis; EPIDERMAL growth factor receptors; RADIONUCLIDE imaging; DIAGNOSIS of bone diseases; NEEDLE biopsy
- Publication
Journal of Cancer Research & Therapeutics, 2015, Vol 11, Issue 3, p652
- ISSN
0973-1482
- Publication type
case study
- DOI
10.4103/0973-1482.138121