We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An aqueous extract of Lespedeza cuneata dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.
- Authors
Jun Kyoung Lee; Li Hua Cao; Dae Gill Kang; Sun Nye Yang; Ho Sub Lee
- Abstract
The aqueous extract of Lespedeza cuneata G. Don (ALC) induced vascular relaxation of the phenylephrine-precontracted aorta in a dose dependent manner, which was abolished by removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) and 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one (ODQ) inhibited the vascular relaxation induced by ALC, respectively. ALC-induced vascular relaxation was also markedly attenuated by addition of verapamil or diltiazem, while the relaxant effect of ALC was not blocked by pretreatment with indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, and propranolol, respectively. Incubation of endothelium-intact thoracic aortic ring with ALC increased the production of cGMP. However, ALC-induced cGMP production was blocked by pretreatment with L-NAME or ODQ. These results suggest that ALC dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.
- Subjects
LESPEDEZA cuneata; PLANT extracts; VASCULAR smooth muscle; NITRIC oxide; CYCLIC guanylic acid; VASODILATION; ENDOTHELIUM
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA1240
- ISSN
0892-6638
- Publication type
Article