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- Title
Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical production.
- Authors
Ongey, Elvis Legala; Neubauer, Peter
- Abstract
Lanthipeptides (also called lantibiotics for those with antibacterial activities) are ribosomally synthesized posttranslationally modified peptides having thioether cross-linked amino acids, lanthionines, as a structural element. Lanthipeptides have conceivable potentials to be used as therapeutics, however, the lack of stable, high-yield, wellcharacterized processes for their sustainable production limit their availability for clinical studies and further pharmaceutical commercialization. Though many reviews have discussed the various techniques that are currently employed to produce lanthipeptides, a direct comparison between these methods to assess industrial applicability has not yet been described. In this review we provide a synoptic comparison of research efforts on total synthesis and in vivo biosynthesis aimed at fostering lanthipeptides production. We further examine current applications and propose measures to enhance product yields. Owing to their elaborate chemical structures, chemical synthesis of these biomolecules is economically less feasible for large-scale applications, and hence biological production seems to be the only realistic alternative.
- Subjects
PEPTIDE synthesis; BIOENGINEERING; ENFUVIRTIDE (Drug); CHEMICAL structure; AMINO acid analysis
- Publication
Microbial Cell Factories, 2016, Vol 15, p1
- ISSN
1475-2859
- Publication type
Article
- DOI
10.1186/s12934-016-0502-y